Dry Eye Disease

Comprehensive Dry Eye Relief
ND101 eye drops are specially formulated to enhance tear production, effectively alleviating dryness and discomfort while promoting the healing of the corneal epithelium.
Superior Tear Film Stability
By improving mucin layer expression, ND101 enhances tear film stability, resulting in better visual clarity and sustained comfort for users, making it ideal for those with dry eye symptoms.
Ocular Protection
ND101 safeguards your eyes from osmotic stress by lowering tear hyperosmolarity, which protects corneal and conjunctival tissues, ensuring long-term ocular health and comfort.
Anti-Inflammatory action
With potent anti-inflammatory properties, ND101 Eye Drops target and neutralize inflammatory mediators, helping to alleviate redness, irritation, and discomfort, thereby promoting overall eye wellness.
Preclinical Proven Effectiveness
Supported by preclinical studies, ND101 has demonstrated its effectiveness in treating dry eyes, offering a scientifically backed solution for those seeking optimal eye health.

1 in 11 affected by Dry eyes world wide

WHAT IS DRY EYE DISEASE?

Often dismissed as a minor discomfort, dry eyes have become a widespread concern worldwide. This condition persists and escalates, causing irritation and vision challenges, affecting people of all ages. Dry Eye Disease occurs when your eyes struggle to maintain a healthy tear film, an essential shield for keeping the eye's surface smooth, clear, and resistant to infections. Imbalances in tear production, quality, or distribution, can occur due to various factors, including physiological changes, environmental influence, or underlying medical conditions. These discrepancies lead to symptoms such as dryness and irritation, which can interfere with daily activities and overall comfort.

Dry eye syndrome can be categorized into two main types: Aqueous deficient and Evaporative dry eyes. Aqueous-deficient dry eye occurs when the eye fails to produce an adequate amount of the watery component of tears. Evaporative dry eye, on the other hand, arises from insufficient oil production, often due to dysfunction of the meibomian glands, leading to increased tear evaporation.

Chronic Condition

Dry eye disease is a chronic condition that requires continuous care.

Gender

Anyone can experience dry eye, but the condition is more common in females than in males.

Hidden Ailment

Dry eye disease often goes unnoticed, especially in older adults, contact lens wearers, individuals with autoimmune conditions, and heavy screen users. Regular eye examinations are crucial for evaluating the integrity of the ocular surface.

1. Rao SK, Mohan R, Gokhale N, Matalia H, Mehta P. Inflammation and dry eye disease-where are we? Int J Ophthalmol. 2022 May 18;15(5):820-827. 2. Golden MI, Meyer JJ, Patel BC. Dry Eye Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. 3. Dry Eye. Available At: https://www.aoa.org/healthy-eyes/eye-and-vision-conditions/dry-eye?sso=y. Last accessed on 09 May 2024 4. Shah S, Jani H. Prevalence and associated factors of dry eye: Our experience in patients above 40 years of age at a Tertiary Care Center. Oman J Ophthalmol. 2015 Sep-Dec;8(3):151-6. 5. Kojima T. Contact lens-associated dry eye disease: recent advances worldwide and in Japan. Investigative ophthalmology & visual science. 2018 Nov 1;59(14):DES102-8. 6. Oncel D, Celebi ARC. Autoimmune Disease-Related Dry Eye Diseases and Their Placement Under the Revised Classification Systems: An Update. Cureus. 2023 Dec 10;15(12):e50276. 7. Akkaya S, Atakan T, Acikalin B, Aksoy S, Ozkurt Y. Effects of long-term computer use on eye dryness. North Clin Istanb. 2018 Aug 8;5(4):319-322.  8. Chen, H., McCann, P., Lien, T. et al. Prevalence of dry eye and Meibomian gland dysfunction in Central and South America: a systematic review and meta-analysis. BMC Ophthalmol 24, 50 (2024) 9.Alves M, Novaes P, Morraye Mde A, Reinach PS, Rocha EM. Is dry eye an environmental disease? Arq Bras Oftalmol. 2014 May-Jun;77(3):193-200 10. Narayanan S, Redfern RL, Miller WL, Nichols KK, McDermott AM. Dry eye disease and microbial keratitis: is there a connection? Ocul Surf. 2013 Apr;11(2):75-92 11. The Environmental Sustainability of Dry Eye Disease. Available At: https://eyewiki.aao.org/The_Environmental_Sustainability_of_Dry_Eye_Disease#cite_note-:3-4. Last accessed on 09 May 2024 12. Data on file

COMPLICATIONS OF UNTREATED EYE DISEASE

Treating dry eyes not only enhances comfort and clarity of vision but also protects against significant ocular health risks. In cases of dry eyes with an unstable tear film, the cornea becomes susceptible to abrasions by particles like dirt or sand. This vulnerability creates an opportunity for bacterial infiltration, potentially leading to severe eye conditions, including conjunctivitis, keratitis, and corneal ulcers.

OUR ONGOING RESEARCH

ND101 eye drops effectively increase tear production, providing relief from dryness and discomfort, while also promoting corneal epithelial wound healing.

Enhancing Tear Production

These eye drops exhibit remarkable anti-inflammatory properties, targeting the inflammatory mediators. By reducing redness and irritation, ND101 creates a conducive environment for overall eye wellness.

Combating inflammation

ND101 eye drops play a significant role in enhancing tear film stability, resulting in improved visual clarity and comfort for the patient.

Improving tear film dynamics

By lowering tear hyperosmolarity, ND101 eye drops help shield corneal and conjunctival tissues from the harmful effects of osmotic stress, thereby safeguarding long-term ocular health.

Protecting against osmotic stress

PREVELANCE

Dry eye disease is a widespread global issue, impacting millions of individuals across different age groups. According to the estimates, dry eye affects approximately 11.59% of the global population and around 8.1% of people in the United States with the occurrence increasing among both younger and older adults. Moreover, geographical factors such as living in arid regions or urban areas can heighten the risk. Given its widespread impact, dry eye disease poses a significant public health challenge.