December 1, 1999
7-methylxanthine effectively modifies rabbit scleral collagen and proteoglycans to support healthy eye structure.
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June 1, 2011
7-methylxanthine reduces form-deprivation myopia and prevents axial elongation in guinea pigs.
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June 1, 2017
7-methylxanthine prevents myopia from hyperopic defocus and induces hyperopia in infant macaques.
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June 25, 2017
7-methylxanthine inhibits adenosine receptor expression in human retinal pigment epithelium cells without affecting cell proliferation or apoptosis.
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April 18, 2012
7-methylxanthine reduces form-deprivation myopia in pigmented rabbits.
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November 4, 2008
7-methylxanthine reduces axial eye growth and myopia progression in children with no rebound effect following treatment discontinuation.
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October 1, 2023
Oral 7-methylxanthine demonstrates real-world efficacy and safety in slowing myopia progression in Danish children.
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January 18, 2024
Real-world evidence from 711 Danish children confirms 7-methylxanthine slows myopia progression in clinical practice.
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June, 2025
7-methylxanthine treatment from age 10 reduces high myopia risk at age 17 in children.
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